simply blood

  Read the last monthly trawl for 2024! We have one preprint, straight from our Community, plus no less than 17 other preprints! Remember, if you want your preprint highlighted here, send it to us using this form ! From the Simply Blood Community: A rare HSC-derived megakaryocyte progenitor accumulates via enhanced survival and contributes to exacerbated thrombopoiesis upon aging https://www.biorxiv.org/content/10.1101/2024.11.04.621964v1  This study identifies an age-dependent, non-canonical pathway for megakaryocyte progenitor (MkP) and platelet production directly from hematopoietic stem cells (HSCs), generating hyperactive platelets linked to age-related thrombotic risks. Single-cell analyses reveal that these non-canonical MkPs exist in both young and aged mice, but aged MkPs exhibit enhanced survival and platelet production, highlighting functional and aging-dependent heterogeneity in megakaryopoiesis. Learn more about this preprint by contacting Bryce Manso at bmanso@uc...

Past and New Members of the NIC at the ISEH 2024 Annual Scientific Meeting in Chicago, USA! View the full list of current NIC members here . The ISEH New Investigators Committee: who we are and what we do for ISEH.  Who is part of the ISEH New Investigators Committee (NIC)? How do we contribute to ISEH? How can I get involved with the NIC or other ISEH committees? Those questions come up often during ISEH events. Their answers might be obvious to some readers, but maybe not so much to other readers. Therefore, we thought it would be useful to provide you with an overview of the ISEH NIC and offer you some advice on how to apply to this super dynamic and friendly committee. This blog post will also introduce you to the 2024-2025 NIC agenda. If you have additional questions, you can also get in touch with us through ISEH or by direct messaging on platforms such as X and Bluesky. Without further ado, let’s get started! What is the composition and role of the NIC? Firstly, the NIC...

The second edition of the Simply Blood Preprint Watch includes 14 preprints, covering clonal dynamics, AML biology and tumor-immune dynamics! We are also happy to showcase a preprint directly contributed by the community, so if you want to see your preprint featured as well, complete a brief submission form . From the Simply Blood Community : A Pax3 lineage gives rise to transient haematopoietic progenitors https://www.biorxiv.org/content/10.1101/2024.06.26.600366v1  This study describes a new source of transient haematopoietic progenitors in the mouse embryo belonging to a Pax3 lineage. These progenitors appear to be transient EMP-like cells that do not originate in the yolk sac and do not persist in adulthood.  STEM AND PROGENITOR CELLS BIOLOGY Hematopoietic Tet2 inactivation enhances the response to checkpoint blockade immunotherapy https://www.biorxiv.org/content/10.1101/2024.09.09.612140v1 Somatic mutations in TET2, a common driver of clonal hematopoiesis, enhance the res...

This week on Simply Blood we interviewed the 2024 Award Winner for Leadership in Diversity, Equity and Inclusion, Katherine King, MD, PhD . Dr. King shares tips and activities to build an inclusive lab environment, how to be a better mentor and role model of DEI, and highlights her lab's research! 2024 Leadership in Diversity, Equity and Inclusion Award Winner Katherine King, MD, PhD Professor, Pediatrics-Infectious Disease Baylor College of Medicine Houston, TX Learn more about Dr. King's contributions to DEI by reading her latest blog post published in Baylor College of Medicine, Easy ways to incorporate inclusion into a busy academic life . Interviewed by Alba Rodriguez-Meira of the ISEH New Investigators Committee. Please note that the statements made by Simply Blood Authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.

  Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Vanuytsel Lab which is based out of the Center for Regenerative Medicine, Boston University. How long has your lab been open and who is in your lab currently? The lab opened in July 2023 and currently consists of a lab manager, a PhD student, a postdoc and three undergraduate researchers. What is the overarching research goal for your group? Our lab studies concepts at the intersection of hematopoietic development, stem cell biology and sickle cell disease. We are trying to gain an in-depth understanding of engraftment potential and how that is orchestrated during development so that we can harness those insights to improve stem cell engraftment in the context of gene therapy and stem cell transplantations. What we learn from stu...

  This month, we're excited to introduce a new series on Simply Blood, where we'll highlight preprints relevant to the ISEH community. We hope you find it engaging, and we welcome any feedback you'd like to share! If there's a specific preprint you enjoyed and would like to see featured, please send it to us using this form ! STEM AND PROGENITOR CELLS BIOLOGY Fetal Liver-like Organoids Recapitulate Blood-Liver Niche Development and Multipotent Hematopoiesis from Human Pluripotent Stem Cells https://www.biorxiv.org/content/10.1101/2024.10.11.617794v1?rss=1  Human Fetal Liver-like Organoids (FLOs) recreate the hepato-hematopoietic interactions of fetal liver development, establishing a niche that supports hematopoietic progenitor differentiation without external factors. In this paper, Rezvani and colleagues show that FLOs can model the integration of hematopoietic and hepatic lineages, showcasing multipotent progenitors with myeloid lineage bias and the potential for fet...