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Mitochondrial Deep Dive into Hematopoietic Stem Cell Dormancy: Not Much Glycolysis but Plenty of Sluggish Lysosomes Jiajing Qiu, Saghi Ghaffari Qiu and Ghaffari review the diverse mechanisms by which cellular metabolism regulates quiescence in adult hematopoietic stem cells, particularly highlighting the role lysosomes and autophagy. Figure 2 The multifaceted role of mitochondria in HSC fate decisions: energy and beyond Marie-Dominique Filippi  Marie-Dominique Filippi reviews the role of mitochondrial metabolism in regulation of the transition from quiescence to activation in hematopoietic stem cells as well as roles in regulating fate decisions.  This review highlights the importance of mitochondrial membrane potential and the factors that control this key determinant of metabolism. Figure 1 HSC-derived fatty acid oxidation in steady-state and stressed hematopoiesis Jayna J. Mistry, Kristian Bowles, Stuart A. Rushworth Mistry et al., discuss the central role of fatty aci...

  Read the last monthly trawl for 2024! We have one preprint, straight from our Community, plus no less than 17 other preprints! Remember, if you want your preprint highlighted here, send it to us using this form ! From the Simply Blood Community: A rare HSC-derived megakaryocyte progenitor accumulates via enhanced survival and contributes to exacerbated thrombopoiesis upon aging https://www.biorxiv.org/content/10.1101/2024.11.04.621964v1  This study identifies an age-dependent, non-canonical pathway for megakaryocyte progenitor (MkP) and platelet production directly from hematopoietic stem cells (HSCs), generating hyperactive platelets linked to age-related thrombotic risks. Single-cell analyses reveal that these non-canonical MkPs exist in both young and aged mice, but aged MkPs exhibit enhanced survival and platelet production, highlighting functional and aging-dependent heterogeneity in megakaryopoiesis. Learn more about this preprint by contacting Bryce Manso at bmanso@uc...

Past and New Members of the NIC at the ISEH 2024 Annual Scientific Meeting in Chicago, USA! View the full list of current NIC members here . The ISEH New Investigators Committee: who we are and what we do for ISEH.  Who is part of the ISEH New Investigators Committee (NIC)? How do we contribute to ISEH? How can I get involved with the NIC or other ISEH committees? Those questions come up often during ISEH events. Their answers might be obvious to some readers, but maybe not so much to other readers. Therefore, we thought it would be useful to provide you with an overview of the ISEH NIC and offer you some advice on how to apply to this super dynamic and friendly committee. This blog post will also introduce you to the 2024-2025 NIC agenda. If you have additional questions, you can also get in touch with us through ISEH or by direct messaging on platforms such as X and Bluesky. Without further ado, let’s get started! What is the composition and role of the NIC? Firstly, the NIC...

The second edition of the Simply Blood Preprint Watch includes 14 preprints, covering clonal dynamics, AML biology and tumor-immune dynamics! We are also happy to showcase a preprint directly contributed by the community, so if you want to see your preprint featured as well, complete a brief submission form . From the Simply Blood Community : A Pax3 lineage gives rise to transient haematopoietic progenitors https://www.biorxiv.org/content/10.1101/2024.06.26.600366v1  This study describes a new source of transient haematopoietic progenitors in the mouse embryo belonging to a Pax3 lineage. These progenitors appear to be transient EMP-like cells that do not originate in the yolk sac and do not persist in adulthood.  STEM AND PROGENITOR CELLS BIOLOGY Hematopoietic Tet2 inactivation enhances the response to checkpoint blockade immunotherapy https://www.biorxiv.org/content/10.1101/2024.09.09.612140v1 Somatic mutations in TET2, a common driver of clonal hematopoiesis, enhance the res...

This week on Simply Blood we interviewed the 2024 Award Winner for Leadership in Diversity, Equity and Inclusion, Katherine King, MD, PhD . Dr. King shares tips and activities to build an inclusive lab environment, how to be a better mentor and role model of DEI, and highlights her lab's research! 2024 Leadership in Diversity, Equity and Inclusion Award Winner Katherine King, MD, PhD Professor, Pediatrics-Infectious Disease Baylor College of Medicine Houston, TX Learn more about Dr. King's contributions to DEI by reading her latest blog post published in Baylor College of Medicine, Easy ways to incorporate inclusion into a busy academic life . Interviewed by Alba Rodriguez-Meira of the ISEH New Investigators Committee. Please note that the statements made by Simply Blood Authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.

  Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Vanuytsel Lab which is based out of the Center for Regenerative Medicine, Boston University. How long has your lab been open and who is in your lab currently? The lab opened in July 2023 and currently consists of a lab manager, a PhD student, a postdoc and three undergraduate researchers. What is the overarching research goal for your group? Our lab studies concepts at the intersection of hematopoietic development, stem cell biology and sickle cell disease. We are trying to gain an in-depth understanding of engraftment potential and how that is orchestrated during development so that we can harness those insights to improve stem cell engraftment in the context of gene therapy and stem cell transplantations. What we learn from stu...

  This month, we're excited to introduce a new series on Simply Blood, where we'll highlight preprints relevant to the ISEH community. We hope you find it engaging, and we welcome any feedback you'd like to share! If there's a specific preprint you enjoyed and would like to see featured, please send it to us using this form ! STEM AND PROGENITOR CELLS BIOLOGY Fetal Liver-like Organoids Recapitulate Blood-Liver Niche Development and Multipotent Hematopoiesis from Human Pluripotent Stem Cells https://www.biorxiv.org/content/10.1101/2024.10.11.617794v1?rss=1  Human Fetal Liver-like Organoids (FLOs) recreate the hepato-hematopoietic interactions of fetal liver development, establishing a niche that supports hematopoietic progenitor differentiation without external factors. In this paper, Rezvani and colleagues show that FLOs can model the integration of hematopoietic and hepatic lineages, showcasing multipotent progenitors with myeloid lineage bias and the potential for fet...

  Experimental Hematology: Young Investigator articles of 2023 Experimental Hematology has reviewed articles published in 2023.   Among the articles highlighted are two Young Investigator articles that both explore important biological questions in normal and malignant hematopoiesis using murine models. Rydström et al investigate how the hematopoietic stem cells regenerate after transplantation. The process where quiescent hematopoietic stem cells start to proliferate to replenish the hematopoietic system, and how they gradually return to homeostasis and quiescence is studied. To capture the dynamics of the process, HSPCs were transplanted and 8 different timepoints surveyed. The repopulating cells were studied at the transcriptional and functional levels. Differential expression of cell cycle genes and metabolic changes were observed during the process. The authors also investigate the functional capacity of the regenerating HSCs and found that it increases with time. A...

  Samanta Mariani’s lab From left to right - Hollie Vaughan (PhD student) - Malgorzata Rumowksa (visiting student) - Samanta Mariani - Hena Modha (Master student) - Eva Doyle (PhD student) Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Mariani Lab which is based out of the Centre for Inflammation Research, The University of Edinburgh. How long have you had your lab and how many members make up your lab?  Three years now. Brief but very intense. Currently, we have two PhD students, one Master student and one visiting student. What is the major research theme of your lab? Our major interest is to understand how embryonic macrophages interact with hematopoietic stem and progenitor cells at steady-state and in mouse models of infant leukemia, where the leukemic cells first a...

  It’s a wrap for the 53rd ISEH Annual Scientific Meeting that took place at the Sheraton Hotel from 29 August - 01 September 2024. Each year, the international community comes together to share the newest techniques and fascinating advances in the field of experimental hematology. This year we were hosted in the windy city with 449 scientists and ISEH members from 30 different countries from around the world that attended (around 40-45% trainees). In contrast to larger conferences like ASH, the ISEH meetings, with fewer than 500 attendees, offer a more intimate setting with exceptional networking opportunities, allowing you to connect with people closely aligned with your work. We would like to start our highlights with a picture from one of our trainees from the New Investigators session: Dr. Xinjian Mao was showing the reconstitution of mouse E11.5 trunk section by Slide-seq and Merfish. Green cells: aortic endothelial cells , Red cells: mesenchymal stromal cells Day 1) Session ...