simply blood

  This month, we're excited to introduce a new series on Simply Blood, where we'll highlight preprints relevant to the ISEH community. We hope you find it engaging, and we welcome any feedback you'd like to share! If there's a specific preprint you enjoyed and would like to see featured, please send it to us using this form ! STEM AND PROGENITOR CELLS BIOLOGY Fetal Liver-like Organoids Recapitulate Blood-Liver Niche Development and Multipotent Hematopoiesis from Human Pluripotent Stem Cells https://www.biorxiv.org/content/10.1101/2024.10.11.617794v1?rss=1  Human Fetal Liver-like Organoids (FLOs) recreate the hepato-hematopoietic interactions of fetal liver development, establishing a niche that supports hematopoietic progenitor differentiation without external factors. In this paper, Rezvani and colleagues show that FLOs can model the integration of hematopoietic and hepatic lineages, showcasing multipotent progenitors with myeloid lineage bias and the potential for fet...

  Experimental Hematology: Young Investigator articles of 2023 Experimental Hematology has reviewed articles published in 2023.   Among the articles highlighted are two Young Investigator articles that both explore important biological questions in normal and malignant hematopoiesis using murine models. Rydström et al investigate how the hematopoietic stem cells regenerate after transplantation. The process where quiescent hematopoietic stem cells start to proliferate to replenish the hematopoietic system, and how they gradually return to homeostasis and quiescence is studied. To capture the dynamics of the process, HSPCs were transplanted and 8 different timepoints surveyed. The repopulating cells were studied at the transcriptional and functional levels. Differential expression of cell cycle genes and metabolic changes were observed during the process. The authors also investigate the functional capacity of the regenerating HSCs and found that it increases with time. A...

  Samanta Mariani’s lab From left to right - Hollie Vaughan (PhD student) - Malgorzata Rumowksa (visiting student) - Samanta Mariani - Hena Modha (Master student) - Eva Doyle (PhD student) Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Mariani Lab which is based out of the Centre for Inflammation Research, The University of Edinburgh. How long have you had your lab and how many members make up your lab?  Three years now. Brief but very intense. Currently, we have two PhD students, one Master student and one visiting student. What is the major research theme of your lab? Our major interest is to understand how embryonic macrophages interact with hematopoietic stem and progenitor cells at steady-state and in mouse models of infant leukemia, where the leukemic cells first a...