Selected Research on HSC Metabolism

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Qiu and Ghaffari review the diverse mechanisms by which cellular metabolism regulates quiescence in adult hematopoietic stem cells, particularly highlighting the role lysosomes and autophagy.

Marie-Dominique Filippi reviews the role of mitochondrial metabolism in regulation of the transition from quiescence to activation in hematopoietic stem cells as well as roles in regulating fate decisions.  This review highlights the importance of mitochondrial membrane potential and the factors that control this key determinant of metabolism.

Figure 1


Jayna J. Mistry, Kristian Bowles, Stuart A. Rushworth

Mistry et al., discuss the central role of fatty acid oxidation in HSCs during steady state hematopoiesis as well as under stress.  The authors highlight the crucial role of fatty acid oxidation in response to infection.


Katharina Schönberger, Nina Cabezas-Wallscheid

Schönberger and Cabezas-Wallscheid review how nutrients derived from diet impact hematopoietic stem cell functions and the metabolic networks that are crucial to their regulation in positive and negative ways.  They particularly highlight the role of nutrient sensing and how these pathways impact core hematopoietic stem cell functions.

Figure 2


Blog post contributed by Grant Rowe, MD, PhD (X: @bloodandtime1, Bluesky @bloodandtime.bsky.social), of the ISEH Publications Committee.

Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.

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