simply blood

  This week on Simply Blood, Shannon McKinney-Freeman sits down with Publications Committee member John Crispino to discuss the purpose and benefits of ISEH, share advice for young investigators, and explore the future direction of ISEH and experimental hematology. Shannon McKinney-Freeman, PhD St. Jude Children's Research Hospital 2024-2025 ISEH President Blog post contributed by John Crispino, PhD, MBA  of the ISEH Publications Committee.  Please note that the statements made by Simply Blood authors are their own views and not necessarily the  views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.

The first monthly trawl for 2025 is plentiful: 9 preprints focusing on Acute Myeloid Leukemia, but also spatial fate mapping meets barcoding, how cell fate decisions occur in hematopoietic progenitors, and more! If there's a specific preprint you enjoyed and would like to see featured, please send it to us using this form . STEM AND PROGENITOR CELLS BIOLOGY Semaphorin 4A maintains functional diversity of the hematopoietic stem cell pool https://www.biorxiv.org/content/10.1101/2024.11.12.622506v1?rss=1 The authors looked at Semaphorin 4A (Sema4A), a protein produced by neutrophils and signaling through Plexin D1, able to protect myeloid-biased hematopoietic stem cells (myHSCs) from inflammatory stress, preserving their epigenetic state and regenerative capacity. In the absence of Sema4A, myHSCs exhibit inflammatory hyper-responsiveness, leading to excessive expansion, myeloid bias, and impaired function with age. Mitochondria Regulate the Cell Fate Decisions of Megakaryocyte-Erythro...