simply blood

Publications Committee Member Alessandro Donada (Institute Curie, Paris, France) recently sat down to interview Dorien Pastoors (Erasmus MC, Rotterdam, Netherlands) and Travis Fleming (Broad Institute, Boston, USA) and discuss their recent preprints on AML Biology. Watch the brief interview and check out their preprints below.  MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia Dorien Pastoors, Marije Havermans, Roger Mulet-Lazaro, Leonie Smeenk, Sophie Ottema, Claudia Erpelinck-Verschueren, Stanley van Herk, Maikel Anthonissen, Tim Grob, Bas J. Wouters, Berna Beverloo, Torsten Haferlach, Claudia Haferlach, Johannes Zuber, Eric Bindels, Ruud Delwel CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias Travis J. Fleming, Mateusz Antoszewski, Sander Lambo, Michael C. Gundry, Riccardo Piussi, Lara Wahlster, Sanjana Shah, Fiona E. Reed, Kevin D. Dong, Joao A. Paulo, Steven P. Gygi, Claudia Mimoso, Seth...

Surprisingly, all scientists go through harsh times. Even the most successful geniuses, like Maria Salomea Skłodowska-Curie, said: "Life is not easy for any of us. But what of that? We must have perseverance and, above all, confidence in ourselves. We must believe we are gifted for something and that this must be attained." Hence, we must all expect and prepare for troubled times. I started my laboratory at Ben-Gurion University of the Negev, Israel, exactly 12 years ago. After a challenging postdoc in Boston, I expected just exciting science, like my joyful years as a PhD student. As you all know, initial excitement inevitably meets reality. After more than 20 years in science, we do not talk about our troubles as much as we should; everybody is happy to share success (and we should!), but not all days are shining. Our training system focuses on the bright side, but the dark side is not confined to a far, far away galaxy – it's always lurking nearby. A scientific career ...

  This month's curated selection of preprints cover some exciting new results on the impact of microenvironment on hematopoietic progenitors, molecular targets for potential new antileukemic agents and novel approaches to long-standing questions like self-renewal and stem cell activity! As usual, if you would like your new preprint highlighted here, submit using this form. From the Simply Blood Community: Dynamic activity of Erg promotes aging of the hematopoietic system  https://www.biorxiv.org/content/10.1101/2025.01.23.634563v1?rss=1 From the authors: “The expression of ETS family transcription factor Erg is temporally regulated. Impaired upregulation of Erg during the hematopoietic maturation results in persistence of juvenile phenotypes.” Path of differentiation defines human macrophage identity https://www.biorxiv.org/content/10.1101/2025.01.24.634694v1 This work display how human fetal liver hematopoietic stem cells generate macrophages through two distinct pathways: a ...

This week on Simply Blood, Dr. Stuart Orkin , Professor of Pediatrics, Harvard Medical School, discusses strategies to being a successful scientist, balancing projects to sustain progress, and career development benchmarks for early stage investigators. Stuart Orkin, MD Professor of Pediatrics, Harvard Medical School Dana-Farber Cancer Institute Boston Children's Hospital Howard Hughes Medical Institute Blog post contributed by Grant Rowe, MD, PhD (X: @bloodandtime1, Bluesky @bloodandtime.bsky.social), of the ISEH Publications Committee. Please note that the statements made by Simply Blood authors are their own views and not necessarily the  views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.

  Patel Lab Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Patel Lab out of the University of Utah/Huntsman Cancer Institute, USA. Can you introduce yourself briefly? I am a physician-scientist in the Division of Hematology and Hematologic Malignancies at the University of Utah/Huntsman Cancer Institute. I see patients with chronic myeloid neoplasms in clinic once a week and also attend on our inpatient leukemia service. I am originally from the Boston suburbs and was in the Chicago area for a long time for my undergraduate degree, medical school and internal medicine residency at Northwestern University. I never thought I would end up in Salt Lake City, Utah, but my husband and I have been here over 10 years now and we absolutely love it! I have a 3-year old son and another kid...