Lab Spotlight: Ganuza Lab
The Ganuza lab has recently reported a germline NOTCH3 mutation, associated with vascular dementia (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy, a.k.a. CADASIL), which is capable of driving expansion of clonal haematopoiesis. This work has made major inroads to answering questions in the role of Notch signalling regulation and how this can favour clonal haematopoiesis (a disorder still very much lacking a deep understanding of the mechanistic drivers) where only vascular dementia has been studied before. We encourage you to read this new research article and interact with the Ganuza lab in the future. Hear from what Miguel has to say below.
How long have you had your lab?
I started my lab in January 2020. There are currently 5 people in the lab including two PhD students and two Postdocs, from England, Greece and Spain.
What is the major research theme of your lab?
Our lab is very interested in the interface between ageing, leukemia and immunity, for which we are investigating cellular interactions in the bone marrow and thymus and mechanisms involved in clonal selection in the hematopoietic system.
I started my lab in January 2020. There are currently 5 people in the lab including two PhD students and two Postdocs, from England, Greece and Spain.
What is the major research theme of your lab?
Our lab is very interested in the interface between ageing, leukemia and immunity, for which we are investigating cellular interactions in the bone marrow and thymus and mechanisms involved in clonal selection in the hematopoietic system.
What's the biggest accomplishment your lab has had recently?
We recently showed that a NOTCH3 mutation responsible for the development of CADASIL, a type of vascular dementia, can also lead to clonal haematopoiesis (CH) and expansion of Dnmt3a-R878H hematopoietic clones. This suggests an unexpected link between CADASIL and CH.
What advice do you have for new investigators just opening their lab?
Creating the right team and environment is the most critical step. Take your time when hiring and strongly support your people.
Does your lab have any fun traditions?
The most established tradition in the lab is our Christmas lunch when we exchange gifts.
Does your lab attend the ISEH Annual Scientific Meeting?
ISEH is our favourite meeting, and we attend it whenever possible. The strong focus of the meeting on trainees is remarkable and offers great training opportunities and the possibility to meet the experimental hematology community in a very friendly environment.
We recently showed that a NOTCH3 mutation responsible for the development of CADASIL, a type of vascular dementia, can also lead to clonal haematopoiesis (CH) and expansion of Dnmt3a-R878H hematopoietic clones. This suggests an unexpected link between CADASIL and CH.
What advice do you have for new investigators just opening their lab?
Creating the right team and environment is the most critical step. Take your time when hiring and strongly support your people.
Does your lab have any fun traditions?
The most established tradition in the lab is our Christmas lunch when we exchange gifts.
Does your lab attend the ISEH Annual Scientific Meeting?
ISEH is our favourite meeting, and we attend it whenever possible. The strong focus of the meeting on trainees is remarkable and offers great training opportunities and the possibility to meet the experimental hematology community in a very friendly environment.
Reach out to Miguel (m.ganuza@qmul.ac.uk) if you are interested in joining his research group. There are PhD and postdoctoral positions open at regular intervals.
Blog post contributed by Bill Grey (@Bill_G_Grey, @billgrey.bsky.social) of the ISEH Publications Committee.
Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.
Comments
Post a Comment