simply blood

  This month's curated selection of preprints cover some exciting new results on the impact of microenvironment on hematopoietic progenitors, molecular targets for potential new antileukemic agents and novel approaches to long-standing questions like self-renewal and stem cell activity! As usual, if you would like your new preprint highlighted here, submit using this form. From the Simply Blood Community: Dynamic activity of Erg promotes aging of the hematopoietic system  https://www.biorxiv.org/content/10.1101/2025.01.23.634563v1?rss=1 From the authors: “The expression of ETS family transcription factor Erg is temporally regulated. Impaired upregulation of Erg during the hematopoietic maturation results in persistence of juvenile phenotypes.” Path of differentiation defines human macrophage identity https://www.biorxiv.org/content/10.1101/2025.01.24.634694v1 This work display how human fetal liver hematopoietic stem cells generate macrophages through two distinct pathways: a ...

This week on Simply Blood, Dr. Stuart Orkin , Professor of Pediatrics, Harvard Medical School, discusses strategies to being a successful scientist, balancing projects to sustain progress, and career development benchmarks for early stage investigators. Stuart Orkin, MD Professor of Pediatrics, Harvard Medical School Dana-Farber Cancer Institute Boston Children's Hospital Howard Hughes Medical Institute Blog post contributed by Grant Rowe, MD, PhD (X: @bloodandtime1, Bluesky @bloodandtime.bsky.social), of the ISEH Publications Committee. Please note that the statements made by Simply Blood authors are their own views and not necessarily the  views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.

  Patel Lab Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Patel Lab out of the University of Utah/Huntsman Cancer Institute, USA. Can you introduce yourself briefly? I am a physician-scientist in the Division of Hematology and Hematologic Malignancies at the University of Utah/Huntsman Cancer Institute. I see patients with chronic myeloid neoplasms in clinic once a week and also attend on our inpatient leukemia service. I am originally from the Boston suburbs and was in the Chicago area for a long time for my undergraduate degree, medical school and internal medicine residency at Northwestern University. I never thought I would end up in Salt Lake City, Utah, but my husband and I have been here over 10 years now and we absolutely love it! I have a 3-year old son and another kid...

  This week on Simply Blood, Shannon McKinney-Freeman sits down with Publications Committee member John Crispino to discuss the purpose and benefits of ISEH, share advice for young investigators, and explore the future direction of ISEH and experimental hematology. Shannon McKinney-Freeman, PhD St. Jude Children's Research Hospital 2024-2025 ISEH President Blog post contributed by John Crispino, PhD, MBA  of the ISEH Publications Committee.  Please note that the statements made by Simply Blood authors are their own views and not necessarily the  views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.

The first monthly trawl for 2025 is plentiful: 9 preprints focusing on Acute Myeloid Leukemia, but also spatial fate mapping meets barcoding, how cell fate decisions occur in hematopoietic progenitors, and more! If there's a specific preprint you enjoyed and would like to see featured, please send it to us using this form . STEM AND PROGENITOR CELLS BIOLOGY Semaphorin 4A maintains functional diversity of the hematopoietic stem cell pool https://www.biorxiv.org/content/10.1101/2024.11.12.622506v1?rss=1 The authors looked at Semaphorin 4A (Sema4A), a protein produced by neutrophils and signaling through Plexin D1, able to protect myeloid-biased hematopoietic stem cells (myHSCs) from inflammatory stress, preserving their epigenetic state and regenerative capacity. In the absence of Sema4A, myHSCs exhibit inflammatory hyper-responsiveness, leading to excessive expansion, myeloid bias, and impaired function with age. Mitochondria Regulate the Cell Fate Decisions of Megakaryocyte-Erythro...

Mitochondrial Deep Dive into Hematopoietic Stem Cell Dormancy: Not Much Glycolysis but Plenty of Sluggish Lysosomes Jiajing Qiu, Saghi Ghaffari Qiu and Ghaffari review the diverse mechanisms by which cellular metabolism regulates quiescence in adult hematopoietic stem cells, particularly highlighting the role lysosomes and autophagy. Figure 2 The multifaceted role of mitochondria in HSC fate decisions: energy and beyond Marie-Dominique Filippi  Marie-Dominique Filippi reviews the role of mitochondrial metabolism in regulation of the transition from quiescence to activation in hematopoietic stem cells as well as roles in regulating fate decisions.  This review highlights the importance of mitochondrial membrane potential and the factors that control this key determinant of metabolism. Figure 1 HSC-derived fatty acid oxidation in steady-state and stressed hematopoiesis Jayna J. Mistry, Kristian Bowles, Stuart A. Rushworth Mistry et al., discuss the central role of fatty aci...