simply blood

This week on Simply Blood we are continuing our 2025 Interview Spotlight Series. In part IV, we are featuring the ISEH 2025 Donald Metcalf Award Winner:  Constanze Bonifer, PhD.  Professor Bonifer dives into her current work, reflects on her most notable discoveries, and highlights scientists that have inspired her throughout her career. Interested in hearing more about Professor Bonifer's fascinating work?   Don’t miss her session at the ISEH 54th Annual Scientific Meeting this September ! Constanze Bonifer, PhD Principal Research Fellow, Murdoch Children's Research Institute Emeritus Professor of Experimental Hematology, University of Birmingham (UK) Read more about Professor Bonifer's work in the  2025 Award Announcement blog. Blog post contributed by Anne Stolz of the ISEH New Investigators Committee. Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising ...

This week on Simply Blood we are continuing our 2025 Interview Spotlight Series. In part III, we are featuring the ISEH 2025 McCulloch and Till Award Winner:  Ulrich Steidl, MD, PhD.  Dr. Steidl dives into his current work, career inspirations, and advice for the young generation of science. Interested in hearing more about Dr. Steidl's fascinating work?   Don’t miss his session at the ISEH 54th Annual Scientific Meeting this September ! Ulrich Steidl, MD, PhD Professor, Department of Cell Biology Professor, Department of Oncology Professor, Department of Medicine Chair, Department of Cell Biology Edward P. Evans Endowed Professor for Myelodysplastic Syndromes Co-Director, Blood Cancer Institute Deputy Director, and Associate Director for Basic Science, Montefiore Einstein Comprehensive Cancer Center Read more about Dr. Steidl's work in the  2025 Award Announcement blog. Blog post contributed by Vu Tran of the ISEH New Investigators Committee. Please note that the st...

This week on Simply Blood we are continuing our 2025 Interview Spotlight Series. In part II, we are featuring the ISEH 2025 Janet Rowley Award Winner: Adam Wilkinson, PhD.  Dr. Wilkinson dives into his current work, how his research has evolved over time, and qualities he looks for in trainees and team members. Interested in hearing more about Dr. Wilkinson's fascinating work?   Don’t miss his session at the ISEH 54th Annual Scientific Meeting this September ! Adam Wilkinson Group Leader, University of Cambridge Department of Hematology Cambridge Stem Cell Institute‬ Read more about Dr. Wilkinson's work in the 2025 Award Announcement blog. Blog post contributed by Jasmin Rettkowski, PhD of the ISEH New Investigators Committee. Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.

This week on Simply Blood we are kicking off our 2025 Interview Spotlight Series. In Part I we are featuring the ISEH 2025 New Investigator Invited Speaker: Shalin Naik, PhD. Prof. Naik dives into his current work, career inspirations, life outside of the lab, and looks towards the future of hematologic research. Interested in hearing more about Prof. Naik's fascinating work? Don’t miss his session at the ISEH 54th Annual Scientific Meeting this September ! Prof. Shalin Naik The Walter and Eliza Hall Institute of Medical Research Laboratory Head Blog post contributed by Kohei Shiroshita, MD, PhD of the ISEH New Investigators Committee. Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.

  Welcome to this month’s Preprint Watch, where we highlight some of the latest and most interesting preprints for the ISEH community. This time, we’re diving into studies using less explored animal models, new angles on normal and pathological lymphopoiesis, and several exciting technologies pushing the boundaries of advanced cell culture. We’re also thrilled to chat with Christiana Georgiou from the Lo Celso Lab in London, UK, who will share more details about her recent work on HSC heterogeneity in the context of malaria infection! As usual, we are more than happy to highlight your new preprint, you just have to submit it at https://www.iseh.org/Preprintwatch !  From the Simply Blood Community: Heterochromatin fidelity is a therapeutic vulnerability in lymphoma and other human cancers https://www.biorxiv.org/content/10.1101/2025.01.31.635709v1 From the authors: We identified the KDM4 family of H3K9 demethylases as subtype-agnostic therapeutic targets for diffuse large B-cel...

Read highlights of the following articles from Experimental Hematology, volumes 143 and 145. A distinct alternative mRNA splicing profile identifies the oncogenic CD44 transcript variant 3 in KMT2A-rearranged pediatric T-cell acute lymphoblastic leukemia cells. Ramilo Amor, Amanda et al. Experimental Hematology, Volume 145, 104712 The recent FDA approval of menin inhibitors targeting key genetic drivers of myeloid leukemia, such as KMT2A (lysine methyl transferase 2A) rearrangements and NPM1 mutations, has drawn attention to a recent article in press in Experimental Hematology.  KMT2A rearrangement (KMT2A-r) is associated with a poorer prognosis in myeloid and lymphoid leukemia. The study is focused on the KMT2A rearrangement in T-ALL and how it is distinct from KMT2A-negative (KMT2A-wt) T-ALL.   The authors performed transcriptome profiling on 171 primary T-ALL samples (n=161 wt vs n=10 KMT2A rearranged samples). They found that 15% of the genes were significantly differ...