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Lab Spotlight: Vanuytsel Lab

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  Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Vanuytsel Lab which is based out of the Center for Regenerative Medicine, Boston University. How long has your lab been open and who is in your lab currently? The lab opened in July 2023 and currently consists of a lab manager, a PhD student, a postdoc and three undergraduate researchers. What is the overarching research goal for your group? Our lab studies concepts at the intersection of hematopoietic development, stem cell biology and sickle cell disease. We are trying to gain an in-depth understanding of engraftment potential and how that is orchestrated during development so that we can harness those insights to improve stem cell engraftment in the context of gene therapy and stem cell transplantations. What we learn from studyin
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Preprint Watch: October

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  This month, we're excited to introduce a new series on Simply Blood, where we'll highlight preprints relevant to the ISEH community. We hope you find it engaging, and we welcome any feedback you'd like to share! If there's a specific preprint you enjoyed and would like to see featured, please send it to us using this form ! STEM AND PROGENITOR CELLS BIOLOGY Fetal Liver-like Organoids Recapitulate Blood-Liver Niche Development and Multipotent Hematopoiesis from Human Pluripotent Stem Cells https://www.biorxiv.org/content/10.1101/2024.10.11.617794v1?rss=1  Human Fetal Liver-like Organoids (FLOs) recreate the hepato-hematopoietic interactions of fetal liver development, establishing a niche that supports hematopoietic progenitor differentiation without external factors. In this paper, Rezvani and colleagues show that FLOs can model the integration of hematopoietic and hepatic lineages, showcasing multipotent progenitors with myeloid lineage bias and the potential for fet
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Exploring Experimental Hematology: October 2024 (Volumes 124 & 127)

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  Experimental Hematology: Young Investigator articles of 2023 Experimental Hematology has reviewed articles published in 2023.   Among the articles highlighted are two Young Investigator articles that both explore important biological questions in normal and malignant hematopoiesis using murine models. Rydström et al investigate how the hematopoietic stem cells regenerate after transplantation. The process where quiescent hematopoietic stem cells start to proliferate to replenish the hematopoietic system, and how they gradually return to homeostasis and quiescence is studied. To capture the dynamics of the process, HSPCs were transplanted and 8 different timepoints surveyed. The repopulating cells were studied at the transcriptional and functional levels. Differential expression of cell cycle genes and metabolic changes were observed during the process. The authors also investigate the functional capacity of the regenerating HSCs and found that it increases with time. Altogether
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Lab Spotlight: Mariani Lab

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  Samanta Mariani’s lab From left to right - Hollie Vaughan (PhD student) - Malgorzata Rumowksa (visiting student) - Samanta Mariani - Hena Modha (Master student) - Eva Doyle (PhD student) Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Mariani Lab which is based out of the Centre for Inflammation Research, The University of Edinburgh. How long have you had your lab and how many members make up your lab?  Three years now. Brief but very intense. Currently, we have two PhD students, one Master student and one visiting student. What is the major research theme of your lab? Our major interest is to understand how embryonic macrophages interact with hematopoietic stem and progenitor cells at steady-state and in mouse models of infant leukemia, where the leukemic cells first appear in
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ISEH 2024 Annual Scientific Meeting - Highlights from the New Investigators Committee

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  It’s a wrap for the 53rd ISEH Annual Scientific Meeting that took place at the Sheraton Hotel from 29 August - 01 September 2024. Each year, the international community comes together to share the newest techniques and fascinating advances in the field of experimental hematology. This year we were hosted in the windy city with 449 scientists and ISEH members from 30 different countries from around the world that attended (around 40-45% trainees). In contrast to larger conferences like ASH, the ISEH meetings, with fewer than 500 attendees, offer a more intimate setting with exceptional networking opportunities, allowing you to connect with people closely aligned with your work. We would like to start our highlights with a picture from one of our trainees from the New Investigators session: Dr. Xinjian Mao was showing the reconstitution of mouse E11.5 trunk section by Slide-seq and Merfish. Green cells: aortic endothelial cells , Red cells: mesenchymal stromal cells Day 1) Session on h
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Thank You 2024 Sponsors and Exhibitors!

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       Thank You Sponsors & Exhibitors The 53rd Annual Scientific Meeting of the International Society for Experimental Hematology meeting is taking place now in Chicago, United States. The exciting program (https://www.iseh.org/page/2024ScientificProgram) includes career and technology sessions, networking events, as well as talks and poster presentations from trainees, new investigators and leaders in the field. On behalf of the ISEH Board of Directors, volunteers and staff, we'd like to thank our 2024 sponsors and exhibitors, seen below. We hope to see you all again in 2025! Funding for this conference was made possible (in part) by 1R13HL176038-01 from the National Heart Lung and Blood Institute (NHLBI). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply
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2024 Interview Spotlight Series: Part IV

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This week on Simply Blood we are closing out our Interview Spotlight Series. In this final part, we are featuring the ISEH 2024 Janet Rowley Award Winner, Robert Signer, PhD . Dr. Signer  shares his career path to becoming a PI, mentorship, advice for early career scientists, and more! Interested in hearing more about  Dr.  Signer's work?  Don’t miss his session at the ISEH 53rd Annual Scientific Meeting this September !     Robert Signer, PhD Principal Investigator, Signer Laboratory Deputy Director, Stem Cell Discovery Center Associate Professor of Medicine, Division of Regenerative Medicine University of California San Diego Interviewed by Els Mansell of the ISEH New Investigators Committee. Please note that the statements made by Simply Blood Authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.
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