Exploring Experimental Hematology: October 2024 (Volumes 124 & 127)
Experimental Hematology: Young Investigator articles of 2023 Experimental Hematology has reviewed articles published in 2023. Among the articles highlighted are two Young Investigator articles that both explore important biological questions in normal and malignant hematopoiesis using murine models. Rydström et al investigate how the hematopoietic stem cells regenerate after transplantation. The process where quiescent hematopoietic stem cells start to proliferate to replenish the hematopoietic system, and how they gradually return to homeostasis and quiescence is studied. To capture the dynamics of the process, HSPCs were transplanted and 8 different timepoints surveyed. The repopulating cells were studied at the transcriptional and functional levels. Differential expression of cell cycle genes and metabolic changes were observed during the process. The authors also investigate the functional capacity of the regenerating HSCs and found that it increases with time. Altogether