simply blood

Mitochondrial Deep Dive into Hematopoietic Stem Cell Dormancy: Not Much Glycolysis but Plenty of Sluggish Lysosomes Jiajing Qiu, Saghi Ghaffari Qiu and Ghaffari review the diverse mechanisms by which cellular metabolism regulates quiescence in adult hematopoietic stem cells, particularly highlighting the role lysosomes and autophagy. Figure 2 The multifaceted role of mitochondria in HSC fate decisions: energy and beyond Marie-Dominique Filippi  Marie-Dominique Filippi reviews the role of mitochondrial metabolism in regulation of the transition from quiescence to activation in hematopoietic stem cells as well as roles in regulating fate decisions.  This review highlights the importance of mitochondrial membrane potential and the factors that control this key determinant of metabolism. Figure 1 HSC-derived fatty acid oxidation in steady-state and stressed hematopoiesis Jayna J. Mistry, Kristian Bowles, Stuart A. Rushworth Mistry et al., discuss the central role of fatty aci...

  Read the last monthly trawl for 2024! We have one preprint, straight from our Community, plus no less than 17 other preprints! Remember, if you want your preprint highlighted here, send it to us using this form ! From the Simply Blood Community: A rare HSC-derived megakaryocyte progenitor accumulates via enhanced survival and contributes to exacerbated thrombopoiesis upon aging https://www.biorxiv.org/content/10.1101/2024.11.04.621964v1  This study identifies an age-dependent, non-canonical pathway for megakaryocyte progenitor (MkP) and platelet production directly from hematopoietic stem cells (HSCs), generating hyperactive platelets linked to age-related thrombotic risks. Single-cell analyses reveal that these non-canonical MkPs exist in both young and aged mice, but aged MkPs exhibit enhanced survival and platelet production, highlighting functional and aging-dependent heterogeneity in megakaryopoiesis. Learn more about this preprint by contacting Bryce Manso at bmanso@uc...

Past and New Members of the NIC at the ISEH 2024 Annual Scientific Meeting in Chicago, USA! View the full list of current NIC members here . The ISEH New Investigators Committee: who we are and what we do for ISEH.  Who is part of the ISEH New Investigators Committee (NIC)? How do we contribute to ISEH? How can I get involved with the NIC or other ISEH committees? Those questions come up often during ISEH events. Their answers might be obvious to some readers, but maybe not so much to other readers. Therefore, we thought it would be useful to provide you with an overview of the ISEH NIC and offer you some advice on how to apply to this super dynamic and friendly committee. This blog post will also introduce you to the 2024-2025 NIC agenda. If you have additional questions, you can also get in touch with us through ISEH or by direct messaging on platforms such as X and Bluesky. Without further ado, let’s get started! What is the composition and role of the NIC? Firstly, the NIC...